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3d insight™ human islet microtissues  (AstraZeneca ltd)

 
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    AstraZeneca ltd 3d insight™ human islet microtissues
    3d Insight™ Human Islet Microtissues, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+insight%E2%84%A2+human+islet+microtissues/3d+insight++human+islet+microtissues/ppr0313516-1355-3-0
    Average 90 stars, based on 1 article reviews
    3d insight™ human islet microtissues - by Bioz Stars, 2026-10
    90/100 stars

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    Article Title: The challenges and considerations for emerging or future entrepreneurial researchers in microphysiological systems
    Article Snippet: AstraZeneca Relies on 3D InsightTM Human Islet Microtissues in Pancreatic Beta-cell Study.



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    a) Stages of islet microtissue production displayed through immunofluorescence staining for insulin (β-cells, green), glucagon (α-cells, red), and somatostatin (δ-cells, blue). Images show (1) native islets in the human pancreas, (2) dissociated islets, and (3) islet <t>microtissues.</t> Scale bar: 100 μm. b) Endocrine-cell compositions of the islet microtissues were calculated from morphometric analysis of the microtissue sections from four individual donors. c) Cross-sectional diameter, d) total ATP content, e) total insulin content, and f) GSIS of human islet microtissues were assessed on days 7, 14, 21, and 28 post production. g) Glucose-stimulated insulin secretion of islet microtissues from 15 different donors 7 d post production is shown. ATP content, insulin content, and secreted insulin were normalized to the islet size in islet equivalents (IEQs), which refer to an islet with 150 μm diameter. Data in panels (c), (d), and (f) have been obtained from islets of seven individual donors, while panel (e) includes data of islets from four individual donors, mean ± standard deviations.
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    Image Search Results


    a) Stages of islet microtissue production displayed through immunofluorescence staining for insulin (β-cells, green), glucagon (α-cells, red), and somatostatin (δ-cells, blue). Images show (1) native islets in the human pancreas, (2) dissociated islets, and (3) islet microtissues. Scale bar: 100 μm. b) Endocrine-cell compositions of the islet microtissues were calculated from morphometric analysis of the microtissue sections from four individual donors. c) Cross-sectional diameter, d) total ATP content, e) total insulin content, and f) GSIS of human islet microtissues were assessed on days 7, 14, 21, and 28 post production. g) Glucose-stimulated insulin secretion of islet microtissues from 15 different donors 7 d post production is shown. ATP content, insulin content, and secreted insulin were normalized to the islet size in islet equivalents (IEQs), which refer to an islet with 150 μm diameter. Data in panels (c), (d), and (f) have been obtained from islets of seven individual donors, while panel (e) includes data of islets from four individual donors, mean ± standard deviations.

    Journal: Advanced biosystems

    Article Title: In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution

    doi: 10.1002/adbi.201900291

    Figure Lengend Snippet: a) Stages of islet microtissue production displayed through immunofluorescence staining for insulin (β-cells, green), glucagon (α-cells, red), and somatostatin (δ-cells, blue). Images show (1) native islets in the human pancreas, (2) dissociated islets, and (3) islet microtissues. Scale bar: 100 μm. b) Endocrine-cell compositions of the islet microtissues were calculated from morphometric analysis of the microtissue sections from four individual donors. c) Cross-sectional diameter, d) total ATP content, e) total insulin content, and f) GSIS of human islet microtissues were assessed on days 7, 14, 21, and 28 post production. g) Glucose-stimulated insulin secretion of islet microtissues from 15 different donors 7 d post production is shown. ATP content, insulin content, and secreted insulin were normalized to the islet size in islet equivalents (IEQs), which refer to an islet with 150 μm diameter. Data in panels (c), (d), and (f) have been obtained from islets of seven individual donors, while panel (e) includes data of islets from four individual donors, mean ± standard deviations.

    Article Snippet: Reaggregated Human Islets InSphero 3D InSight human islet microtissues were produced by hanging-drop-based scaffold-free reaggregation of dispersed primary human islets obtained through Prodo Laboratories Inc. Irvine, CA.

    Techniques: Immunofluorescence, Staining

    a) Stages of islet microtissue production displayed through immunofluorescence staining for insulin (β-cells, green), glucagon (α-cells, red), and somatostatin (δ-cells, blue). Images show (1) native islets in the human pancreas, (2) dissociated islets, and (3) islet microtissues. Scale bar: 100 μm. b) Endocrine-cell compositions of the islet microtissues were calculated from morphometric analysis of the microtissue sections from four individual donors. c) Cross-sectional diameter, d) total ATP content, e) total insulin content, and f) GSIS of human islet microtissues were assessed on days 7, 14, 21, and 28 post production. g) Glucose-stimulated insulin secretion of islet microtissues from 15 different donors 7 d post production is shown. ATP content, insulin content, and secreted insulin were normalized to the islet size in islet equivalents (IEQs), which refer to an islet with 150 μm diameter. Data in panels (c), (d), and (f) have been obtained from islets of seven individual donors, while panel (e) includes data of islets from four individual donors, mean ± standard deviations.

    Journal: Advanced biosystems

    Article Title: In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution

    doi: 10.1002/adbi.201900291

    Figure Lengend Snippet: a) Stages of islet microtissue production displayed through immunofluorescence staining for insulin (β-cells, green), glucagon (α-cells, red), and somatostatin (δ-cells, blue). Images show (1) native islets in the human pancreas, (2) dissociated islets, and (3) islet microtissues. Scale bar: 100 μm. b) Endocrine-cell compositions of the islet microtissues were calculated from morphometric analysis of the microtissue sections from four individual donors. c) Cross-sectional diameter, d) total ATP content, e) total insulin content, and f) GSIS of human islet microtissues were assessed on days 7, 14, 21, and 28 post production. g) Glucose-stimulated insulin secretion of islet microtissues from 15 different donors 7 d post production is shown. ATP content, insulin content, and secreted insulin were normalized to the islet size in islet equivalents (IEQs), which refer to an islet with 150 μm diameter. Data in panels (c), (d), and (f) have been obtained from islets of seven individual donors, while panel (e) includes data of islets from four individual donors, mean ± standard deviations.

    Article Snippet: Reaggregated Human Islets InSphero 3D InSight human islet microtissues were produced by hanging-drop-based scaffold-free reaggregation of dispersed primary human islets obtained through Prodo Laboratories Inc. Irvine, CA.

    Techniques: Immunofluorescence, Staining